The proportion of menopausal women has been increased and the women over 50's
will be composed the half of all women in 2030 year. And it is reasonable to consider
that most women will benefit from hormone replacement therapy. Also it is important to
realize that cardiovascular disease is a major cause of morbidity and mortality in
menopausal women.
These are the clinical date that evaluate the clinical effect of hormone replacement
therapy by several methods on lipids and lipoproteins in postmenopausal women,
especially hypercholesterolemic patients.
we treated 158 cases of postmenopausal women who visited Chung-Ang University
Yong-san hospital from January 1992 to December 1995. We divided the patient into 5
groups and evaluated the lipoproteins and lipid changes after 3months:
Group I(surgical menopausal women) received premarin only; Group II received 3 day
on & off method; Group III received continuous sequential method.
Group IV received cyclic sequential method; Group V received continuous combined
method.
The results are as follows.
1. changes in serum lipid and lipoprotein level after hormone replacement therapy. Total
cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C, triglyceride, LP(a) were decreased
but HDL-C was not changed.
2. changes in serum lipid and lipoprotein level on estrogen only treated group and
estrogen plus progesterone combined treat groups
1) estrogen only treated group
Total cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C were decreased and HDL-C
was increased, but triglyceride and LP(a) was not changed.
2) estrogen plus progesterone combined treated groups
Total cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C, triglyceride, LP(a) were
decreased but HDL-C was not changed.
3. changes in serum lipid and lipoprotein level on different combined method treated
group.
1) 3 day on & off method
Total cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C were decreased but HDL-C,
triglyceride and Lp(a) were not changed.
2) continuous sequential method
Total cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C were decreased but HDL-C,
triglyceride and Lp(a) were not changed.
3) cyclic sequential method
Total cholesterol, LDL-C, HDL-C, triglyceride were decreased but atherogenic index,
LDL-C/HDL-C and Lp(a) were not changed.
4) continuous combined method
Total cholesterol, LDL-C, atherogenic index, LDL-C/HDL-C were decreased but HDL-C,
triglyceride and Lp(a) were not changed.
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